Pre – Formulation and Evaluation of Jamu Uyup – Uyup (an Indonesian Herbal Galactogogue)

Abstract

Jamu Uyup – Uyup has established as the most used natural galactagogue in Indonesia, especially among Javanese people. Jamu Uyup – Uyup is available on the market in the fresh liquid form of a herbal mixture. Liquid forms of herbal preparations have certain limitation related to large dose volumes, difficult packaging, and poor stability. Developing and formulation Jamu Uyup - Uyup into solid dosage form would ensure reproducibility of product quality, accurate doses, improve acceptability and easy compliance with usage directives. The preparation of solid dosage form was carried out using spray drying technique. Microparticle comprising Jamu Uyup – Uyup encapsulated in a lactose matrix have medium yellow color, have distinct typical odor of Zingiberaceae, taste mildly bitter, pungent, slightly sweet, and have an acidic pH (4.7) to keep curcuminoids content stable. The solid dosage form had moisture content of 3.21 ° 1.71% dw and curcuminoids content of 35.86 ± 2.13 mg/g dw. Surface morphology showed that microparticles containing Jamu Uyup – Uyup encapsulated in a lactose matrix have spherical shape with a smooth surface and various sizes (20 – 100 μm) with no apparent cracks or fissures.