Abstract
Invasive fungal diseases are frequent causes of treatment-related morbidity and mortality in children with haematological malignancies or allogeneic haematopoietic stem-cell transplantation, and their control is an important goal of infectious-disease supportive care in these populations. Over the past three decades, several antifungal strategies have been developed to meet this goal, including antifungal prophylaxis, empirical antifungal therapy, and pre-emptive antifungal therapy. Although they are not mutually exclusive, each of these strategies is characterised by specific advantages and disadvantages, and the preference of a specific strategy depends on factors such as the local epidemiology, individual patient-related risk profiles, and the paediatric validation and availability of diagnostic options.
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