Abstract
The aim of this study was to compare the effect of dexamethasone 8mg and methylprednisolone 40mg for the control of pain, swelling, and trismus following the extraction of impacted third molars. Sixteen healthy patients with a mean age of 20.3 (standard deviation 1.25) years received a single oral dose of either drug 1h prior to each surgical procedure (left and right teeth). At 24, 48, and 72h and 7 days following surgery, swelling was determined using linear measurements on the face and trismus was determined by maximal mouth opening. Postoperative pain was self-recorded by the patients using a visual analogue scale at 8-h intervals for a period of 72h. Data analysis involved descriptive statistics and the Wilcoxon, and paired t tests (P<0.05). Dexamethasone controlled swelling better than methylprednisolone at all postoperative evaluations (P<0.02) and led to greater mouth opening 48h after surgery (P=0.029). No statistically significant difference was found between drugs with regard to pain. In conclusion, pre-emptive dexamethasone 8mg demonstrated better control of swelling and limited mouth opening in comparison to methylprednisolone 40mg, with no differences between drugs regarding pain control.
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