PRE-CLINICAL STUDIES OF IVERMECTIN SOLID DISPERSION

Abstract

For deworming of horses of drove breeding and wild animals in preserves of free feeding, we have developed an innovative drug based on ivermectin using the technology of mechanochemical modification of ivermectin substance with a mixture of polymers (polyvinylpyrrolidone /PVP/ and arabinogalactan /AG/ Siberian larch Larix sibirica). With this treatment, a solid dispersion of ivermectin (SDI) was obtained in the form of a beige powder, which is easily flowable. The pharmaceutical safety of SDI was studied, the parameters of general toxicity, acute cutaneous toxicity, irritant effects, and the effect of the drug on the eye mucosa were studied. Studies conducted on white mongrel rats. The LD50 of the study drug was found to exceed the test dose. According to GOST 12.1.007-76, the drug belongs to the 4th class of hazard (low hazardous substances). In the study of local irritation of the drug on the skin, it was noted that the integrity of healthy skin on the other hand, where the scratches were not injured, elasticity remained, there was no redness, after a month the sheared layer was healthy. Established the absence of irritating properties of SDI with a single application to the skin. As a result of studying the irritant effect of the drug on the mucous membrane of the eye, it was established that SDI has a moderate local irritant effect on the eyes of animals, estimated at 1 point.