Pre-Clinical Evaluation of Anti-Diabetic Activity of Phyllanthus Reticulatus Fruit Extract

Abstract

Anti-diabetic activity of Phyllanthus Reticulatus fruit extract was carried out against streptozotocin induced diabetic model in wistar rats. Soxhlet extraction using methanol was carried out on Phyllanthus Reticulatus fruit to obtain the extract. Acute Oral Toxicity– Acute Toxic Class Method 423 was performed to obtain the low and high doses respectively at 300 mg/kg and 600 mg/kg. Experiment using streptozotocin as diabetic model was actioned. The parameters which were evaluated were body weight, blood glucose, SOD (superoxide dismutase), CAT (catalase), GSH (glutathione), MDA (malondial- dehyde), Triglyceride (TG), Total cholesterol (TC), HDL (high-density lipoprotein) and LDL (low-density lipoprotein). Streptozotocin brought derangements in the above estimated parameters which were ameliorated by administration of Phyllanthus Reticulatus fruit extract. The findings of the present study support anti-diabetic activity of Phyllanthus Reticulatus fruit extract in the animal model.