Pre-angiography total ST-segment resolution is not a reliable predictor of an open infarct-related artery

Abstract

BackgroundWhile the cutoffs of predictive value for ST-segment elevations resolution (STSR) following thrombolysis and/or primary PCI were well documented, the impact of pre-angiography STSR has not been established yet. ObjectivesThe aim of this study is to assess prognostic utility of pre-angiography STSR to predict pre-procedural TIMI flow in the infarct-related artery (IRA) and infarct size in STEMI patients undergoing primary PCI. MethodsA prospective study was performed, including 310 patients, admitted within 12h of symptom onset and who underwent primary PCI. ST-segment elevations were measured in: (1) qualifying ECG, (2) ECG before angiography, and (3) ECG post PCI. STSR was defined as: total (≥70%), partial (between 70% and 30%) and none (<30%). Relationships between pre-angiography STSR, initial TIMI flow and troponin T level (TnT) were analyzed. ResultsPre-angiography STSR correlated with initial TIMI flow in the IRA (rS=0.619; p<0.001). Pre-angiography total STSR was observed in 23.2% patients. It was noted in 79.2% of patients with pre-procedural TIMI flow ≥2 and in 20.8% with TIMI flow ≤1 (p<0.001). Although the sensitivity of pre-angiography total STSR to detect pre-procedural TIMI flow ≥2 was 93%, its specificity was only 56% and the likelihood ratio was 2.1. Pre-angiography total STSR was associated with lower peak TnT level (2.2±2.5ng/ml vs. 6.4±5.0ng/ml, p<0.0001) when compared to the remaining patients. Conclusions1. Pre-angiography STSR correlates with preprocedural TIMI flow. 2. The sensitivity of pre-angiography total STSR in detection of pre-procedural TIMI flow ≥2 is high, but low specificity of only 56% makes it an unreliable predictor of an open IRA.