Abstract
Ischemic preconditioning (PC) is a myocardial endogenous protection against ischemia. It has been described as one or several short ischemia before a sustained ischemia. This short ischemia triggers a protective signal against this longer ischemia. An ischemic organ is able to precondition a remote organ. It is possible to replace the short ischemia by a preadministration of halogenated volatile anaesthetic with the same protective effect, this is called APC. Anaesthetic PC and ischemic PC share similar underlying biochemical mechanisms including protein kinase C, tyrosine kinase activation and mitochondrial and sarcolemnal KATP channels opening. All halogenated anaesthetics can produce an anaesthetic PC effect. Myocardial protection during reperfusion, after the long ischemia, has been shown by successive short ischemia or volatile anaesthetic administration, this is called postconditioning. Ischemic PC has been described in humans in 1993. Clinical studies in human cardiac surgery have shown the possibility of anaesthetic PC with volatile anaesthetics. These studies have shown a decrease of postoperative troponin in patient receiving halogenated anaesthetics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
