Abstract
PRAX-114 is a GABA-A receptor positive allosteric modulator (GABAA-R-PAM) neuroactive steroid which achieves preferential potentiation of extrasynaptic GABAAR compared to synaptic GABAAR. GABAAR-PAMs cause increases in EEG β-frequency band power. The effects of PRAX-114 on quantitative EEG (qEEG) were measured in rodents and healthy human volunteers.
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