Abstract
Many metabolic diseases are caused by disruption of lipid homeostasis.
Highlights
Metabolic syndrome is one of the major global escalating public health concerns.[1]
Previous studies have reported that 25-HC blocks SREBPs processing by binding to Insigs, triggering their binding to SREBP cleavage-activating protein (SCAP) and retaining the SCAP/SREBP complex in the endoplasmic reticulum (ER).24 25-HC signi cancy decreased the levels of mature SREBP-1 and -2 (Fig. 1D), but upregulated the precursor SREBP levels (Fig. 1D), because of activating LXR that in turn upregulates the transcription of SREBP
These results indicated that praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels in vitro
Summary
Metabolic syndrome is one of the major global escalating public health concerns.[1] Hyperlipidemia is closely related to metabolic diseases, such as insulin resistance, type 2 diabetes mellitus (T2DM) and atherosclerosis.[2,3] regulating the signaling pathway of lipid metabolism and inhibition of the accumulation of triglyceride and cholesterol are important targets for preventing obesity and associated metabolic diseases.[3,4,5]. Peucedani Radix (Qian-Hu in Chinese), the dried roots of Peucedanum praeruptorum Dunn, has been widely applied for the therapy of cough with thick sputum and dyspnea, nonproductive cough and upper respiratory infections in traditional medicinal assay.[15,16,17,18] There are several types of compounds reported in Peucedani Radix, and the major constituents are coumarins containing praeruptorin A, B, C, D and E. The aim of this study is to investigate the hypolipidemic effect of praeruptorin B and unravel the mechanism of praeruptorin B on lipid metabolism by targeting SREBPs pathway
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