Abstract
The authors provide a personal perspective of method development in thin-layer chromatography for the novice and more experienced chromatographer alike. No attempt has been made at a comprehensive survey of the literature. Instead we provide an overview with insights into a smaller number of approaches that the authors have found useful in their own work and indicate the factors responsible for the variation in retention and their control. The main topics covered are the relationship between sorbent chemistry and retention, the selection of primary solvents for mobile phase optimization and mobile phase optimization using the PRISMA and solvation parameter models.
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