Practice improves motor control in older adults by increasing the motor unit modulation from 13 to 30 Hz

Abstract

Practice of a motor task decreases motor output variability in older adults and is associated with adaptations of discharge activity of single motor units. In this study we were interested in the practice-induced modulation of multiple motor units within 13-30 Hz because theoretically it enhances the timing of active motoneurons. Our purpose, therefore, was to determine the neural adaptation of multiple motor units and related improvements in movement control following practice. Nine healthy older adults (65-85 yr) performed 40 practice trials of a sinusoidal task (0.12 Hz) with their index finger (10° range of motion). Multi-motor unit activity was recorded intramuscularly from the first dorsal interosseus muscle. The mean spike rate (MSR), spike rate variability (CV(ISI)), and frequency modulation (5-60 Hz) of the spike rate were calculated from the multi-motor unit activity and were correlated with movement accuracy and variability of index finger position. A decrease in movement trajectory variability was associated with an increase in MSR (R(2) = 0.58), a decrease in CV(ISI) (R(2) = 0.58), and an increase in total power within a 13- to 30-Hz band (R(2) = 0.48). The increase in total power within a 13- to 30-Hz band was associated significantly (P < 0.005) with an increase in MSR (R(2) = 0.75) and the decrease in CV(ISI) (R(2) = 0.70). We demonstrate that practice-induced improvements in movement control are associated with changes in activity of multiple motor units. These findings suggest that practice-induced improvements in movement steadiness of older adults are associated with changes in the modulation of the motoneuron pool from 13 to 30 Hz.