Abstract
AbstractIn synthesizing novel derivatives of the natural cyclic peptides the ogipeptins, we established a simple and practical solid-phase peptide synthesis and macrocyclization method. By using this method, it became possible to obtain skeleton-modified ogipeptin derivatives with dehydroxylation of the β-hydroxy-α,γ-diaminobutyric acid, replacement of the (Z)-dehydrobutyrine residue, or replacement of the arginine residue.
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