Abstract
The enantioselective synthesis of aromatic bisabolanes, such as 1,3,5-bisabolatrien-7-ol, peniciaculin A and B, and hydroxysydonic acid, has been described. Our methodology for the total synthesis of aromatic bisabolanes involves the stereoselective construction of the C-7 stereogenic center via a Sharpless asymmetric dihydroxylation reaction, followed by a SmI 2 -mediated Julia olefination. Preliminary results obtained for the odor evaluation of 1,3,5-bisabolatrien-7-ol and the confirmation of the absolute configurations of peniciaculin A and B are also described.
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