Abstract
Reaction of a set of enaminones with 2-chloronicotinoyl chloride or 2,6-dichloro-5-fluoronicotinoyl chloride mainly leads to N-acylation products which cyclize directly or reacting with sodium hydride to give 8-acyl-7-alkyl-1,6-naphthyridin-5(6 H)-ones. Due to their easy availability these compounds are attractive precursors for synthesis of polycondensed heterocycles like naphtho[2,3- h][1,6]naphthyridin-5-ones and pyrido[3,2- c][1,6]naphthyridin-6-ones.
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