Abstract
At present, taking into account the widespread application of pharmacogenetics’ achievements to all branches of medicine, it has become possible to conduct such research in ophthalmology. At the moment, the studies on the most broadly used glaucoma medications have been carried out. The correlations between patients’ genotypes and the frequency of occurrence of adverse side effects have been found. The further exploration of the pharmacogenetics of the glaucoma medications and the introduction of pharmacogenetic testing will enable ophthalmologists to assign a rational, safe, and effective treatment in the short time, which will considerably improve the quality of provided aid.
Highlights
The further exploration of the pharmacogenetics of the glaucoma medications and the introduction of pharmacogenetic testing will enable ophthalmologists to assign a rational, safe, and effective treatment in the short time, which will considerably improve the quality of provided aid
[Sychev DA, Ramenskaya GV, Ignatiev IV et al Klinicheskaya farmakogenetika
Summary
Бета-адреноблокаторы, используемые в офтальмологической практике, включают неселективные, тимолола малеат, и β1-селективные препараты, бетаксолол. Неселективные бета-адреноблокаторы имеют достоверно большую эффективность, по сравнению с β1-селективными препаратами [10]. Блокируя β1- и β2-адренорецепторы цилиарного тела, препараты снижают уровень ВГД за счёт уменьшения продукции внутриглазной жидкости [1, 9]
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