Practical, Highly Active, and Enantioselective Ferrocenyl–Imidazoline Palladacycle Catalysts (FIPs) for the Aza‐Claisen Rearrangement of N‐para‐Methoxyphenyl Trifluoroacetimidates

Abstract

Just a pinch of catalyst: Just 0.05 mol % of a novel planar chiral ferrocenyl–imidazoline palladacycle catalyst (FIP) is sufficient to catalyze a highly efficient aza-Claisen rearrangement of N-para-methoxyphenyl trifluoroacetimidates and thereby provide access to chiral protected primary allylic amines with unprecedentedly high enantioselectivities (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601731_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.