Abstract
To ensure the quality and efficiency of pathogen inactivation of buffy coat platelet concentrates by the INTERCEPT™ Blood System it is necessary to standardise the products, to streamline the logistics and to consider data management options thoroughly. During the optimisation period, the number of buffy coat platelets pooled was increased from 4 to 5, and the secondary centrifugation (soft spin) time was increased to 5 min. The additional workload compared with standard procedures was approximately 10 min when few concentrates were prepared simultaneously. The data management system ensured the quality of the process. After optimisation, the average platelet yield was 3.17 × 10<sup>11</sup> with a standard deviation (SD) of 0.39. The average pH on storage day 7 was 6.87 (SD: 0.06), and the swirling was excellent. Due to the documented effects of the inactivation procedure and the documented quality of the products, we have omitted bacterial surveillance and irradiation of the INTERCEPT platelets, and we store the platelets for up to 7 days before transfusion, in accordance with national guidelines.
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