Practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid

Nathan J Line

doi:10.1016/j.tetlet.2019.04.023

Practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid

Nathan J Line

https://doi.org/10.1016/j.tetlet.2019.04.023

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Journal: Tetrahedron Letters	Publication Date: Apr 13, 2019
Citations: 1

Affiliation: Albany Molecular Research (United States)

#One-pot Azide #Practical Synthesis + Show 3 more

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Abstract

A practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid was accomplished via an unconventional Evans anti-aldol reaction followed by a one-pot azide reduction/reductive cyclization.

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