Abstract
A practical, efficient and general method was developed for the deprotection of a variety of aromatic and aliphatic acetals to their corresponding catechol or diol derivatives using thiol immobilized on silica gel. This is an application for the well‐known commercial solid‐supported thiol (SiliaMetS® Thiol). The procedure is mild and amenable to scale‐up. It does not require inert atmosphere and clean conversions were observed. This method is applicable to substituted 1,3‐benzodioxole and aliphatic acetals with different functionalities. It offers the advantage of a general route with high yield, which can be undertaken at ambient temperature.
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