Abstract

Oral immunotherapy (OIT) is now widely recognized as a valid option for the management of IgE-mediated food allergies. However, in real-life practice, OIT can lead to a variety of unique situations where the best course of action is undetermined. In patient-centered care, individual patient preferences, needs and values, should guide all clinical decisions. This can be achieved by using shared-decision making and treatment customization to navigate areas of uncertainty in a way that is responsive to patient’s needs and preferences. However, in the context of OIT, lack of awareness of potential protocol adaptability or alternatives can become a barrier to treatment personalization. The purpose of this article is to review the theoretical bases of patient-centered care and shared decision-making and their practical implication for the patient-centered delivery of OIT. Clinical cases highlighting common challenges in real-life OIT practice are presented along with a discussion of potential personalized management options to be considered. While the practice of OIT is bound to evolve as additional scientific and experiential knowledge is gained, it should always remain rooted in the general principles of patient-centered care.

Highlights

  • Oral immunotherapy (OIT) is recognized as a reasonable alternative to strict avoidance for the management of IgE-mediated food allergies

  • Recent Canadian guidelines have made clear recommendations concerning the initiation of OIT for the treatment of patients with IgE-mediated food allergy [1], based on evidence and a diversity of ethical imperatives

  • The purpose of this review is to present practical aspects of oral immunotherapy treatment personalization in real-life aimed at clinicians interested in developing an OIT clinical offer rooted in the principles of patient-centered care (PCC)

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Summary

Introduction

Oral immunotherapy (OIT) is recognized as a reasonable alternative to strict avoidance for the management of IgE-mediated food allergies. The purpose of this review is to present practical aspects of oral immunotherapy treatment personalization in real-life aimed at clinicians interested in developing an OIT clinical offer rooted in the principles of PCC. The article introduces cases depicting common clinical challenges seen in OIT practice where there is no clear single best approach. These are meant to serve as a practicum illustrating the creation of choice awareness in real life rather than to provide a “right answer”. The objective is not Graham et al Allergy Asthma Clin Immunol (2021) 17:31 to provide definitive answers to each case but rather to provide clinicians with examples of adaptive thinking and SDM that will help them determine the “right answer” for each individual patient, which should be the standard approach for the optimal delivery of patient-centered OIT

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