Abstract
The 1,2-diamine motif is widely present in natural products, pharmaceutical compounds, and catalysts used in asymmetric synthesis. The simultaneous introduction of two amino groups across an alkene feedstock is an appealing yet challenging approach for the synthesis of 1,2-diamines, primarily due to the inhibitory effect of the diamine products to transition metal catalysts and the difficulty in controlling reaction diastereoselectivity and regioselectivity. Herein we report a scalable electrocatalytic 1,2-diamination reaction that can be used to convert stable, easily available aryl alkenes and sulfamides to 1,2-diamines with excellent diastereoselectivity. Monosubstituted sulfamides react in a regioselective manner to afford 1,2-diamines bearing different substituents on the two amino groups. The combination of an organic redox catalyst and electricity not only obviates the use of any transition metal catalyst and oxidizing reagent, but also ensures broad reaction compatibility with a variety of electronically and sterically diverse substrates.
Highlights
The 1,2-diamine motif is widely present in natural products, pharmaceutical compounds, and catalysts used in asymmetric synthesis
Significant progress has been achieved over the past decades in alkene 1,2-diamination and 1,2-diazidation reactions, mainly through transition metal catalysis (Fig. 1a, b
Building on our experience with electrochemical alkene difunctionalization37,38, we report a diastereoselective electrocatalytic 1,2-diamination reaction of di- and tri-substituted alkenes using available and stable sulfamides as amino donors
Summary
The 1,2-diamine motif is widely present in natural products, pharmaceutical compounds, and catalysts used in asymmetric synthesis. Significant progress has been achieved over the past decades in alkene 1,2-diamination and 1,2-diazidation reactions, mainly through transition metal catalysis (Fig. 1a, b)3–18. Diastereoselective Differentiated amino groups Transition metal- and oxidizing reagent-free poor differentiation of the two amino groups in the diamine products.
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