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Abstract
Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates. However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. There was also lack of pan-cancer evidence for the relationship between PPP1R14B and various tumor types based on abundant clinical data. We used the TCGA project and GEO databases to perform pan-cancer analysis of PPP1R14B, including expression differences, correlations between expression levels and survival, genetic alteration, immune infiltration, and relevant cellular pathways, to investigate the functions and potential mechanisms of PPP1R14B in the pathogenesis or clinical prognosis of different cancers. Herein, we found that PPP1R14B was involved in the prognosis of pan-cancer and closely related to immune infiltration. Increased PPP1R14B expression correlated with poor prognosis and increased immune infiltration levels in myeloid-derived suppressor cells (MDSCs). Our studies suggest that PPP1R14B can be used as a prognostic biomarker for pan-cancer. Our findings may provide an antitumor strategy targeting PPP1R14B, including manipulation of tumor cell growth or the tumor microenvironment, especially myeloid-derived suppressor cell infiltration.
Highlights
Protein phosphatase 1 (PP1) is an ubiquitous Ser-/Thr-specific phosphatase that regulates various cellular processes and has multiple functions in cellular processes, including RNA splicing, protein synthesis, cell cycle progression, and glycogen metabolism (Choy et al, 2012)
A study showed that the 3-gene expression signatures composed of SCGB2A1, KLF4, and PPP1R14B can differentiate a group of circa 5% of cases with short survival in chronic lymphocytic leukemia (CLL) patients, which is useful for further studies regarding disease prognostication and drug response in CLL (Orgueira et al, 2019)
The results showed that PPP1R14B was highly expressed in BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC compared with their adjacent normal tissues (Figure 2A)
Summary
Protein phosphatase 1 (PP1) is an ubiquitous Ser-/Thr-specific phosphatase that regulates various cellular processes and has multiple functions in cellular processes, including RNA splicing, protein synthesis, cell cycle progression, and glycogen metabolism (Choy et al, 2012). PP1 plays a key role in stress recovery but promotes apoptosis when cells are damaged and cannot be repaired. It participates in neuronal excitement and ion channel transport. The PPP1R14B protein is capable of inhibiting PP1 as well as different PP1 holoenzymes. It is named phosphatase holoenzyme inhibitor 1 (PHI-1) (Eto et al, 1999). The PPP1R14B gene is known as PLCB3N, SOM172, and PNG
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