Abstract
Pd catalyst has been widely used in modern synthesis. However, the soaring palladium price in the past years has limited its use due to the high cost. Lowering down the loading of Pd in Pd-catalyzed reactions may help to solve the problem. Here an example of ppm (part per million) scale Pd used in Sonogashira reaction is presented, using the melamine-based resin as supporter of the Pd atom, with TON up to 20,000 in aqueous phase. This method was proved by 20 entries using different aryl bromides with various terminal alkynes, and good to excellent yields were obtained in most cases.
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