PPAR GAMMA AGONISTS: AN EFFECTIVE STRATEGY FOR CANCER TREATMENT

Abstract

PPAR - γ regulates cellular differentiation , development and metabolism. They play these essential roles by functioning as transcription factors regulating the expression of genes. The PPARs mainly are of three types α, β and γ. The PPAR - γ expressed in three forms γ1, γ2 and γ3 present in different tissues. When PPAR binds its ligand, transcription of target gene is increased or decreased. Tzds were able to i nduce cell differentiation and apoptosis or inhibit cell proliferation both in vitro and in vivo . However , widespread use of thiazolidinediones (TZDs), the clinically used synthetic PPAR gamma agonists, has been limited by adverse effects . S o in this revie w we are suggesting some new molecules other than thiazolidine diones which can act as potential anticancer agents, after explaining the mechanism of action of PPAR - γ agonists as anticancer agents especially thiazolidinediones .