Abstract
Copper(II)-diacetyl-bis(N4-methylthiosemi-carbazone) [Cu(II)ATSM] was developed as a selective positron emission tomography agent for imaging hypoxia, however the mechanism of its intracellular retention remains to be elucidated. Recent studies have highlighted the neuroprotective effects of Cu(II)ATSM against nitrosative damage in a mouse model of amyotrophic lateral sclerosis. As Cu(II)ATSM has also been shown to reduce peroxynitrite levels and oxidative stress in vitro, we sought to assess the effects of Cu(II)ATSM on activation of the Nrf2 defence pathway and protection against angiotensin II (Ang II) mediated apoptosis in human coronary artery smooth muscle cells (HCASMC). Treatment of HCASMC with Ang II (200nM, 12h) significantly increased apoptosis detected by annexin V fluorescence (P Supported by Heart Research UK (NET01/13).
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