Abstract
Responsiveness to extracellular signals may participate in the control of cell division. This hypothesis was examined by comparing the adenosine responsiveness of Rous sarcoma virus (RSV)-transformed cells and untransformed cells. The results show that RSV-transformed chicken embryo cells (CEC) are more responsive to adenosine than Rous associated virus (RAV)-infected or normal CEC. Experiments using temperature-sensitive, transformation-defective (ts-td) RSV-CEC grown under permissive and restrictive temperatures exhibit the same differences as RSV- and RAV-infected cells, respectively. Moreover, the ts-td virus-infected cells exhibit an enhanced adenosine responsiveness within 1 h following a shift from the restrictive to the permissive temperature. These data indicate that increased adenosine responsiveness is an early event in RSV-induced transformation of CEC.
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