Abstract
Aim The main purpose of our investigation was to study the concentration of oxidized proteins and malondialdehyde (MDA) in blood plasma from patients with community-acquired pneumonia (CAP). Methods Patients were divided into 2 groups. 29 patients with community-acquired pneumonia moderate severity and respiratory insufficiency of grade 2 were included in the 1-st group. The control group consisted of 32 healthy persons. All patients and healthy subjects had received the full information on probable inconveniences at the blood sampling before giving their written informed consent. The protein reactive carbonyl derivatives, advanced oxidative proteins products (AOPP), and malondialdehyde (MDA) were detected in blood plasma. Comparisons of the results obtained between patients and healthy persons were performed using non-parametric Mann-Whitney U-test (for independent variables). Results Our results showed the significant increase in AOPP (by 2 times, p Conclusion The data showed synchronous increase of AOPP and MDA in blood plasma from CAP patients. AOPP is considered to be formed from oxidized albumin, fibrinogen. The probability of reaction of AOPP with MDA and cross-linking increases. It promotes oxidative stress over time and contributes to hypoxia progression in CAP patients.
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