Abstract
Methods: Clinical data of 523 preterm infants who had received PN for more than 7 days were reviewed. Among them, 250 cases were preterm infants without any complications (group 1). Two hundred and seventy-three cases were preterminfants with complications (including asphyxia, septicemia, pneumonia, hyaline membrane disease, and necrotizing enterocolitis) (group 2). The incidence of parenteral nutrition-associated cholestasis (PNAC) between these two groups was compared and risk factors of PNAC were analyzed. Results: Total incidence of PNAC in preterm infants was 8.8%. The incidence of PNAC in group 1 and that in group 2 were 4.4% and 12.8%, respectively. The average gestational age and birth weight of PNAC group were less and lower than those of the non-PNAC group. The time to start enteric feeding was delayed, and daily weight gain was less in the PNAC group. Average PN duration was longer, calorie intake was higher in the PNAC group. Age of starting oral nutrition and birth weight regain time were earlier in the preterm infants without complications. Conclusion: The incidence of PNAC was associated with lower gestational age, lower birth weight, longer duration of PN, higher calorie intake, later enteric feeding, and complications of prematurity.
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