PP.20.31

Abstract

Objective: The objective of our study was to assess the dynamics of vascular wall stiffness and central aortic pressure in patients with an active form of acromegaly after adenomectomy. Design and method: We examined 52 patients with active acromegaly, and 14 patients (4 men, 10 women; average age - 50,7 ± 10,6 years) underwent transnasal adenomectomy. The mean disease duration was 7.84 (1–30) years. Hypertension was diagnosed in 11 patients. At baseline and 12 months after the surgery all patients underwent applanation tonometry for the assessment of vascular stiffness and central blood pressure (BP) (Sphygmocor, Australia). Results: Baseline parameters were as following: pulse wave velocity (PWV) 6.44 ± 1.49 m/c, central systolic BP 113.6 ± 12.3 mmHg, central diastolic BP 73.1 ± 10.2 mm Hg, augmentation index (AI) 22.2 ± 13.1%. Compared to baseline parameters, 12 months after the surgery there was a significant increase of central systolic and diastolic BP on average by 8 (4; 13) and 8 (1; 13.5) mm Hg, respectively (p = 0.004 and p = 0.006). Office BP increased by an average of 10 (-0.5; 17) mm Hg (p = 0.026). The elevation of PWV and AI was also registered 12 months post-surgery, however, the changes were non-significant: 0.46 (0.07; 2.45) m/s and 5 (1.5; 10)%, respectively (p = 0.13; p = 0.12). Conclusions: In patients with acromegaly average parameters of vascular stiffness and central BP are within the normal range. Twelve months after adenomectomy there is a significant increase in central BP along with the elevation of the office BP, which is probably due to the lack of hypertension control in the postoperative period.