PP.19.27

Abstract

Objective: Original ultrasonic approach for subcutaneous and abdominal fat measurement is proposed for assessment of body fat distribution. The relationship between ultrasonic lipometric indicators and cardio-metabolic profile in a general population was not studied. We investigated the relationship between subcutaneous and premesenteric fat repositories and metabolic syndrome (MS) in a population-based sample. Design and method: We used data from a random population sample (n = 163; men, women aged 18-64) examined in EPOGH Project. Subcutaneous fat (SCF) thickness and premesenteric fat (PMF) thickness and width were measured on transverse images with conventional ultrasound in epigastric area and validated against CT (n = 40). Data on CVD risk factors and anthropometry (body mass index, BMI; waist-to-hip ratio, WHR; skin fold) were collected. MS was defined by IDF, 2006. Correlates of fat measures were assessed in multivariable linear regression. Prediction of MS by SCF and PMF was tested in ROC analysis. Results: Mean SCF thickness was of 1.25 cm (SD 0.55), mean PMF thickness was of 1.52 cm (SD 0.63). Both fat measures were associated with BMI, WHR, and skin fold. Determinants of SCF thickness were female sex (p = 0.042), systolic blood pressure (SBP) (p = 0.051), insulin (p = 0.034). Determinants of PMF thickness were SBP (p = 0.001), insulin (p = 0.03), and total cholesterol (p = 0.037). Additionally, PMF was negatively associated with HDL-C (p = 0.021). In ROC analysis PMF thickness and width were strong predictors of MS with AUC = 0.78 (p < 0.0001) and AUC = 0.82 (p < 0.0001). In age-, sex-adjusted logistic regression PMF thickness > 1.6 cm, and PMF width > 7.0 cm significantly increased risk of MS (OR = 4.5, p = 0.016 and OR = 4.5, p = 0.015). The SCF thickness > 1.3 cm increased risk of MS with OR = 4.9, p = 0.027. Conclusions: Sonographic indicators of subcutaneous and premesenteric fat are independently associated with insulin, SBP, female sex (SCF). Additionally, PMF but not SCF was positively associated with total cholesterol and negatively with HDL-C. All ultrasonic measures increased risk of MS in dose-dependent fashion. Reference values of 1.6 cm for PMF thickness, 7.0 cm for width, and 1.3 cm for SCF thickness were predictive for MS. Sonographic indicators are supposed to be screening ’non-lab’ tool for central adiposity and MS detection.