PP187: Merkel cell carcinoma of head and neck region: A case series of six patients from northern Greece

Abstract

Merkel Cell Carcinoma (MCC) is a rare and aggressive primary neuroendocrine carcinoma of the skin. Most patients are in their seventh decade or older and only 5% of all reported patients are below the age of 50. MCC shows a propensity for sun-damaged skin and it is characterized by increased rates of locoregional recurrences, distant metastases, and disease-related deaths. It is estimated that more than one-half of all cases arise in the head and neck region. In this retrospective study we included all registered cases of primary MCCs of the head and neck which were managed in the Oral and Maxillofacial Surgery (OMFS) department of Theageneion Anticancer Hospital of Thessaloniki during the last 11 years. Six patients – 4 women and 2 men – over 62 years of age were identified. Treatment selection, response and overall course are described in detail for all patients. Management of head and neck MCCs requires early and accurate diagnosis and includes surgery, radiotherapy, and/or chemotherapy. Clinical staging is crucial for any treatment decisions. Since the majority of MCCs arise on the head and neck region, OMF surgeons are among those health care providers, who may be the first to encounter with this disease and should be aware of all treatment modalities.