Abstract
The interplay between uptake and efflux transporters determines hepatic concentrations of drugs. Gd-BOPTA is a contrast agent used in liver magnetic resonance (MR) imaging that enters into human hepatocytes through OATP and exit unchanged into bile through MRP2. Rifampicin (RIF) is transported by the same membrane proteins and may compete with Gd-BOPTA for hepatic uptake. The aim of the study was then to elucidate the acute cellular interactions between Gd-BOPTA and RIF in perfused rat liver preparations.
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