PP175-SUN CONSEQUENCES OF CATHETER-RELATED INFECTIONS IN PATIENTS WITH INTESTINAL FAILURE. RESULTS EXTRACTED FROM THE WORLD LARGEST SINGLE CENTER DATABASE

Abstract

lead to a stabilisation or even an improvement of the bone mineral density (BMD) on the long range. Methods: Retrospective study of patients under HPN followed by the Gastroenterology Service of St-Luc Hospital from 2004 to 2011. Exclusion criteria were the lack of data on BMD or the absence of an osteodensitometry at the beginning of the HPN. Follow-up included regular visits with an endocrinologist, an initial dual energy X-ray absorptiometry at the start of HPN and every two years thereafter. BMD at the hip (g/cm2) were collected and their evolution was measured. A reduction or an increase in BMD was considered significant for a drop or a rise of 0.04 g/cm2 respectively. Results: 44 patients under HPN were identified. Data on BMD were collected for 30 individuals. A mean of 4 dual energy X-ray absorptiometry were performed for each patient. On average, we observed a drop of 0.01 g/cm2 (95% confidence interval (CI); drop of 0.03 rise of 0.01 g/cm2) in BMD for the entire follow-up. Globally, more than 70% of individuals showed a stabilisation or an increase in their BMD on the long range. It looks like there was no difference in the evolution of the bone status between people with osteoporosis initially and those without osteoporosis at the beginning of HPN. In addition, a small waiting time between the diagnosis of intestinal insufficiency and the beginning of HPN seems to ensure a better constancy of the BMD (odds ratio: 5.8; P value = 0.19). This trend seems similar when the duration of HPN was short (odds ratio: 4.5; P value = 0.16). Conclusion: An adequate follow-up of patients under HPN ensures a stabilisation of BMD on the long range.