PP-165 MOXIFLOXACIN-DEPENDENT TORSADES DE POINTES

Abstract

Objective: This study aimed to analyze safety, efficacy, and follow up results of percutaneous closure of patent ductus arteriosus (PDA) with Amplatzer and Cook coil devices in children under 1 year of age. Methods: We retrospectively analyzed data on 33 patients younger than 12 months in whom transcatheter closure PDA between July 2005 and January 2010. Results: Ages ranged from 1.5 to 12 (median, 8) months and body weight from 2.4 to 14 (7.0) kg. Ductus diameter ranged from 2 to 5 (3.0) mm and pulmonary to systemic flow ratio from 1 to 10 (2.3). The Amplatzer duct occluder (ADO) device was used at nineteen patients and Cook coil was used at eighteen patients. Four of coil embolisation procedures were failed. In two patients Amplatzer device was placed after the coil was removed because of residual PDA. In one patient ADO was placed because of residual PDA after coil occlusion. In the last patient coil was migrated to pulmonary artery, we couldn’t remove it and placed an ADO for PDA closure. The other major complications were defined as minimal pericardial effusion (1 patient), mild left pulmonary artery stenosis (1 patient), mild coarctation at descending aorta which was resolved by weight gain. Conclusions: We found that in children under one year of age, transcatheter closure of PDA by using Amplatzer and Cook coil occluder are safe and effective procedures. Improvements in the devices and experiences of the interventionists are decreasing the complication rate.