Abstract
The objective of the study was to determine the renal clearance of metformin in healthy Caucasian volunteers with and without the polymorphism c.808G>T (rs316019) in OCT2 and the relevance of gene–gene interactions between c.808 (G>T) and the promoter SNP g.-66T>C (rs2252281) in MATE1 and between c.808 (G>T) and the OCT1 reduced-function diplotypes.
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