Abstract
Several pharmacogenetic algorithms have been developed to achieve the desired acenocoumarol therapeutic range as soon as possible to reduce the risk of hemorrhagic events or progression of the thrombotic disease. The main SNPs recognized to influence the adequate acenocoumarol dosing are located in CYP2C9, VKORC1, and recently CYP4F2 and APOE genes (Borobia et al. PLoS One 7(7):e41360). POR is required for drug metabolism by all microsomal cytochrome P450 enzymes and has been arisen their influence in warfarin dose.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
