Abstract
Several pharmacogenetic algorithms have been developed to achieve the desired acenocoumarol therapeutic range as soon as possible to reduce the risk of hemorrhagic events or progression of the thrombotic disease. The main SNPs recognized to influence the adequate acenocoumarol dosing are located in CYP2C9, VKORC1, and recently CYP4F2 and APOE genes (Borobia et al. PLoS One 7(7):e41360). POR is required for drug metabolism by all microsomal cytochrome P450 enzymes and has been arisen their influence in warfarin dose.
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