Abstract
Purpose: The immunologic effects of radiation (RT) are influenced by RT dose and each may be optimized over a unique dose range. We hypothesized that a heterogeneous dose of RT might thereby optimally engage multiple immune pathways and allow for greater immune activation compared to homogenous RT dose. We used brachytherapy (BT) to deliver a heterogeneous RT dose within a single tumor and we compared the relative capacities of BT and homogenous dose external beam radiotherapy (EBRT) to enhance the anti-tumor immune response in combination with immune checkpoint inhibition (ICI).
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