PP123-MON THE ASSOCIATION BETWEEN DIETARY INTAKE OF SODIUM AND CARDIOVASCULAR RISK FACTORS IN PEOPLE WITH TYPE 1 AND TYPE 2 DIABETES

Abstract

Rationale: Sodium intake is positively associated with cardiovascular disease risk. The aim was to investigate the correlation between predicted 24 hour urinary sodium excretion and carotid intima media thickness (cIMT), central blood pressure, augmentation index and pulse wave velocity in people with type 1 and type 2 diabetes. Methods: Participants (age 55.5±17.1years) were 62 adults with type 1 (n = 16) or type 2 (n = 46) diabetes recruited from the community. Common cIMT was measured using B-mode ultrasound. Predicted 24 hour urinary sodium excretion was calculated from a random spot urine sample using the formula: spot urine sodium concentration/spot urine creatinine concentration × predicted 24 hour creatinine ( 2.04·age + 14.89·weight + 16.14·height [cm] 2244.45). In a sub-sample of the cohort (n = 19; type 1 diabetes n = 3; type 2 diabetes n = 16) a SphygmoCor® XCELwas used to measure central blood pressure, augmentation index and pulse wave velocity. Results: Mean predicted 24 hour urinary sodium excretion was 202±150mmol/24hrs. Twenty four hour predicted sodium excretion was positively correlated with mean and maximum left cIMT (r = 0.295 and 0.286; both p 0.05). Predicted urinary sodium excretion was positively correlated with central systolic blood pressure (r = 0.549), central diastolic blood pressure (r = 0.462) and mean arterial pressure (r = 0.469) after adjustment for age (n = 19; p < 0.05). Augmentation index and pulse wave velocity were not associated with predicted sodium excretion. Conclusion: In this relatively small cohort of people with type 1 and type 2 diabetes dietary sodium intake was positively associated with central blood pressure. However, no relationship was found between sodium and cIMT. These relationships will be explored in a larger cohort of people with diabetes.