PP.11.18] CROSSTALK BETWEEN VITAMIN D, LDL, HIGH SENSITIVITY C REACTIVE PROTEIN AND CARDIOVASCULAR RISK IN HYPERTENSIVE PATIENTS

Abstract

Objective: To assess the relationship between vitamin D, LDL and high sensitivity C reactive protein (hsCRP) in hypertensive patients. Design and method: 25-hydroxy-vitamin D, hsCRP and LDL level were assessed in 30 middle-aged (47 ± 5 years) hypertensive patients. Cardiovascular risk was evaluated considering hsCRP values: high cardiovascular risk if hsCRP exceeded 0.300 mg/dL, moderate if 0.100–0.300 mg/dL and low if less than 0.100 mg/dL. Results: Vitamin D, hsCRP and LDL levels were as follows: 27.16 ± 11.51 microg/L, 0.53 ± 0.49 mg/dL and 139 ± 41 mg/dL. Vitamin D was insufficient (less than 20 microg/L) in 9 patients (30%), high sensitivity C reactive protein and LDL were increased (more than 0.3 mg/dL and 130 mg/dL, respectively) in 17 patients (57%). A LDL exceeding 130 mg/dL was a sensitive predictor of high cardiovascular risk (sensitivity: 0.71, 95%CI: 0.44–0.88) and a specific predictor of moderate cardiovascular risk (specificity: 0.8, 95%CI: 0.29–0.98). Low vitamin D level was found as a specific predictor of high cardiovascular risk (specificity: 0.69, 95% CI: 0.38–0.89). Conclusions: Insufficient vitamin D levels, and high LDL and hsCRP are very prevalent in middle-aged hypertensive patients, related to a high or moderate cardiovascular risk.