PP-099 IS THERE ANY RELATION BETWEEN CIRCULATING ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULE-1 AND EXTENT OF CORONARY ARTERY INVOLVEMENTS IN MEN WITH ANGINA PECTORIS?

Abstract

Background-Selectins as a group of adhesion molecule arise from the surface of activated cell and involved for atherosclerotic plaque production. Objective-To evaluate the relationship between Circulating Endothelial-Leukocyte adhesion molecule -1 (E-selectin) and the extent of coronary artery involvement in male Patients with coronary heart disease (CHD). MethodsParticipants were 103 male patients with symptoms of CHD. Patients underwent coronary angiography and according to angiography results they were divided to 80 patients with severe CHD and 23 with mild coronary involvements according to angiographic score. The Circulating E-selectin level was compared in both groups by ELISA method. Anova and analysis of covariant (ANCOVA) were used for evaluating possible association of E-selectin level and severity of coronary artery involvement by adjusting age, history of diabetes mellitus, hypertension, and dyslipidemia. ResultsThe mean age of 103 male patients was 58.32±9.42 years. The E-selectin level was not significantly different in both groups with sever and minimal (CHD) (P=0.78). ANCOVA test could not show after significant association between E-selectin level and the extent of coronary artery involvement adjusting age (P=0.94) as well as history of diabetes mellitus, hypertension, and dyslepidemia respectively (P=0.43). ConclusionThe circulating E-selectin level have no association with the severity of CHD in male patients(Iranian Heart Journal 2011; 12 (4):37-42). Key Word : Adhesion molecule■ E-selectin■ CAD■ coronary angiography■ extent Received June. 16, 2011; Accepted for publication Feb. 10, 2012 1. Associated Professor of Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Assistant Researcher, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Cardiology Fellow, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan, Iran. 4. MS, MS, Biologist, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan, Iran. 5. Researcher, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran. 6. Professor of Cardiology, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan, Iran. Correspondence to: Masoumeh Sadeghi, MD. Head of CVD in Women Department Isfahan Cardiovascular Research Institute WHO Collaborating Center. (http://crc.mui.ac.ir) Isfahan University of Medical Sciences (http://mui.ac.ir) PO BOX: 81465-1148 Phone: +98 311 3359797 Fax: +98 311 3373435 Email: sadeghimasoumeh@gmail.com Ar ch iv of S ID