PP.09.03] CONCORDANCE BETWEEN TWO FORMS OF ARTERIAL STIFFNESS REGISTER AND CORRELATION WITH BRACHIAL AND CENTRAL BLOOD PRESSURE

Abstract

Objective: Carotid-femoral pulse wave velocity (cfPWV) is recognized as the gold standard for the assessment of arterial stiffness. Cardio Ankle Vascular Index (CAVI), which is determined automatically has been proposed as an alternative. We aimed to assess the correlation between these two methods and their association with central and peripheral BP. Design and method: These is an observational study in 43 essential hypertensive patients, 60% males, aged 48 ± 14 years. cfPWV was determined by pulse waveform analysis using the validated and calibrated Sphygmocor Xcel device (AtCor Medical, West Ryde, Australia). Brachial and central BP (transfer function) were determined used the same device. CAVI and the ankle-brachial index were determined by VaSera VS-Series Vascular Screening System (Fukuda Denshi, Tokyo, Japan). Agreement between the two methods was assessed by both Pearson's and intraclass correlation coefficients. The correlation between either cfPWV or CAVI with central and peripheral BP were estimated by Pearson's correlation coefficients and possible differences evaluated by calculating z-statistics. Results: Mean values of cfPWV CAVI were respectively 7.5 ± 1.9 m/s and 8.6 ± 2.0 units. The concordance between CAVI and PWV was considered good (Pearson's correlation coefficient of 0.724 (p < 0.001) and intraclass correlation coefficient of 0.840). Correlations were all significants for both cfPWV and CAVI and for both central and peripheral SBP and PP. No differences were observed between the intensity of correlation obtained by CAVI or PWV (non-significant z statistics). Conclusions: There is a good correlation between the measurement of arterial stiffness by PWV and CAVI, and both measures are similarly correlated with BP.