Abstract
to assess nutritional and immunological biomarkers. Fecal samples were collected before and after the intervention. Results: Increases in IgA levels tended to be higher in the BB536 group than in the placebo group. The percentage of subjects with a positive antibody titer toward A/H1N1 was significantly higher at week 6 in the BB536 group than in the placebo group. NK cell activity decreased significantly only in the placebo group during the intervention period. Changes in NK cell activity tended to be higher in the BB536 group compared to the placebo group. Significantly higher numbers of bifidobacteria and B. longum subsp were observed in the BB536 group after the intervention. Conclusion: Long-term ingestion of the probiotic BB536 modulated innate and adaptive immune function. There were no adverse effects from the ingestion of BB536. These results suggest that BB536 ingestion could help improve the health status of the elderly.
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