PP075. Poor renal function following hypertensive pregnancy: Older mothers and smaller babies

Abstract

There is increasing evidence that hypertensive pregnancy is a risk factor for renal disease [1]. To examine the correlation between maternal and offspring characteristics and impaired glomerular filtration rate following a hypertensive pregnancy. We calculated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) formula corrected for body surface area in a cohort of 422 women at 6 weeks following a pregnancy complicated by all types of hypertension (pre-eclampsia, gestational hypertension, essential hypertension with and without superimposed pre-eclampsia). We performed statistical analysis using Spearmans rho to examine for correlations with maternal and fetal characteristics. 2.1% women had poor renal function at 6 weeks after delivery with a GFR <60ml/min/1.73m(2). Older mothers were more likely to have a lower GFR (p=0.001). Women with poor renal function at 6 weeks were more likely to have had a low birth weight baby (p=0.002). The median birth weight for women with GFR<60ml/min/1.73m(2) was 2.85kg as opposed to 3.23kg for women with a GFR >60ml/min/1.73m(2). Clinically significant renal impairment following a hypertensive pregnancy is a rare. Advancing maternal age represents an important risk factor for on-going renal disease in this population. Small babies are more likely in a hypertensive pregnancy [2] and may also represent a marker for poorer maternal health after birth in this population.