Abstract
Hypoxia is closely related to malignant progress, angiogenesis, invasion, metastasis and tolerance of treatment in malignant tumor. But the precise molecular mechanism of hypoxia is not clear in oral squamous cell carcinoma (OSCC). In this study, for the first time we investigated interrelationship between hypoxia and Prx1 during tumor growth in human OSCC xenograft model. Eighty tumors were divided into four groups according to a mean tumor diameter of 2, 5, 10, and 15 mm. 2 mm group was set as control. 5, 10, and 15 mm were experimental groups. Pimonidazole staining, immunohistochemistry, QRT-PCR, Western blot, ELISA were used to detect hypoxia, MVD, 8-OHdG, Prx1, HO-1 and NF-B genes. The results showed the extent of tumor hypoxia increased compared with control with tumor size increasing (p
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