Abstract
Objective To investigate the significance of prothrombotic single nucleotide polymorphisms (SNPs) and their combinations as the significant risk factor of transient ischemic attacks (TIA) in children. Methods Case-control study: 52 patients were compared with 117 controls. 10 single nucleotide polymorphisms (SNPs) in blood coagulation and folic acid cycle's enzymes genes were identified. Inclusion criteria TIA's debut at the age under 18 y.o.; slavic origin; no changes on brain CT (MRI) and spinal tap. Results All patients had 2.84±0.17 vs 2.36±0.08 thrombophilic SNPs (p>0.05) and 2.16±0.13 vs 1.64±0.08 (p A, ITGA2: 807 C>T, ITGB3: 1565 T>C and PAI-1: –675 5G>4G differed significantly in TIA patients (OR=3.40–7.07, p Conclusion The number of thrombophilic SNPs and incident of the most severe (F2:G20210A, F5:G1691A, MTHFR:C677T) do not play the important role in TIA's patients in childhood. The combination 3 SNPs in genes of folic acid cycle's enzymes can increase the risk of TIA in children. There are no clear genes' combinations which inevitably lead to TIA, but we consider FGB: –455 G>A, PAI-1: –675 5G>4G and “sticky platelet” SNPs seems to be the good applicants to become such genes-candidates combinations.
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