PP027: Primary Hodgkin’s lymphoma: A rare manifestation in the hard palate

Abstract

Purpose To report the rare involvement of the hard palate as the only manifestation of Classical Hodgkin Lymphoma and the differential diagnosis with other infections and lymphoproliferative disorders of oral mucosa. Material and methods A 43-year-old white female complained of a 6 month history of sore throat. The physical examination revealed an ulcer measuring 2.0 cm on the hard palate that presented communication with nasal cavity. The initial diagnostic hypotheses were leishmaniosis, tuberculosis or infectious cutaneous mucosal diseases. Results Analytical results of infectious agents were negative. An incisional biopsy showed lymphoplasmocitary infiltrate, with presence of Hodgkin and Reed-Sternberg cells, that exhibited immunoreactivity to CD30 and Fascina and nonreactivity to CD15, CD45, CD56, CD20, CD3 and TIA1, supporting a diagnosis of classical Hodgkin lymphoma, Ann Arbor clinical stage I-A. The patient was submitted to three cycles of chemotherapy (ABVD) and there was no evidence of disease at 15 months of follow-up. Conclusions The primary extranodal Hodgkin’s lymphoma of the oral cavity suggests a new diagnostic and epidemiological perspective, that it may be associated with a new disease. So, it should be included in the differential diagnosis of ulcerative lesions of the palate.