PP022—Variations in drug-induced liver injury (DILI) between different prospective dili registries

Abstract

e24 Volume 35 Number 8S PP022—VARIATIONS IN DRUG-INDUCED LIVER INJURY (DILI) BETWEEN DIFFERENT PROSPECTIVE DILI REGISTRIES I. Medina-Caliz; A. Gonzalez-Jimenez; F. Bessone; N. Hernandez; A. Sanchez; M. Di Pace; M. Arrese; J.R. Brahm; A. Ruiz; J. Arancibia; D. Kershenobich; A. Loaeza; M. Girala; N. Mendez-Sanchez; M. Davalos; M. Lizarzabal; E. Mengual; C. Stephens; M. Robles-Diaz; R.J. Andrade; and M.I. Lucena H.U. Virgen de la Victoria, Universidad de Malaga, IBIMA, CIBEReHD, Malaga, Spain; H del Centenario, Rosario, Argentina; H de Clinicas, Montevideo, Uruguay; Pontificia Universidad Catolica de Chile; H Clinico Universitario de Chile, Santiago, Chile; H General de Mexico, Mexico City, Mexico; H. de Clinicas Asuncion, Asuncion, Paraguay; Fundacion Clinica Medica Sur, Mexico City, Mexico; H Rebagliati, Lima, Peru; and H Maracaibo, Maracaibo, Venezuela, Bolivarian Republic Of Introduction: DILI differs across geographical areas due to differential drug polices, prescription habits, drug consumption, and genetic factors. In this study, we have compared DILI cases included in the recently established Latin American DILI Network with those in the Spanish DILI Registry and the US Drug-Induced Liver Injury Network to identify differences in phenotypic presentations and causative agents. Patients (or Materials) and Methods: Demographic, clinical parameters, and causative agents were compared between 98 Latin American, 851 Spanish, and 300 US DILI cases. Results: The Latin American cases had a mean age of 54 years with a predominance of females (61%), whereas mean age and female proportion in the Spanish and US DILI cases were 54 years with 49% females and 48 years with 60% females, respectively. The most common type of liver damage in all 3 registries was hepatocellular injury. Jaundice was frequently seen in the registries, with 70%, 66%, and 69% of the Latin American, Spanish, and US DILI cases, respectively. Hospitalization occurred in 51% of the Latin American DILI cases, with 57% and 60% of the Spanish and US cases requiring hospitalization. Liver-related death or liver transplantation occurred in 5.1%, 3.6%, and 6.0% of the Latin American, Spanish, and US cases, respectively. The main causative agents in Latin America included nimesulide, diclofenac, nitrofurantoin, cyproterone acetate, and various herbal remedies, whereas amoxicillin-clavulanate predominated in the other 2 registries, followed by ibuprofen in Spain and nitrofurantoin in the United States. Conclusion: The Latin American DILI cases demonstrate similar phenotypic characteristics as observed in registers outside Latin America with respect to type of injury and severity. Female sex predominates in the Latin America and US registries. With regard to causative agents, elevated representation of NSAIDs, hormonal treatments, and herbal remedies were seen in Latin America, whereas antibiotics were more common causes of DILI in Spain and the United States. Funding Source: Agencia Espanola del Medicamento, SAS P10CTS-6470, FIS PI12-00620, iSAEC. CIBERehd by ISCIII. Disclosure of Interest: None declared.