PP014: Comparison of oncologic outcomes between major and minor salviary gland adenoid cystic carcinoma (ACC)

Abstract

Purposes The purpose of our study was to compare the oncologic outcome between major and minor salivary gland ACC during the 18-year follow-up. Materials and methods The records of 61 consecutive patients with ACC were reviewed. Thirty patients had major gland ACC and 31 patients had minor gland ACC. Stage I–II disease was found in 36 patients and stage III–IV disease was found in 25 patients. Surgical treatment was performed in all patients. Adjuvant treatment was applied if indicated. Results There were no significant differences in patients or tumor characteristics between major and minor gland ACC. Local and regional recurrence rates were similar ( Table 1 ). However, minor gland ACC had shorter duration of regional recurrence significantly. The overall survival rate was 79.8% at 5 years, 76.85% at 10 years and 64.04% at 15 years. Survival rate and duration were not different in both groups. However, when we compared the patients who had no evidence of disease (NED) status and who had alive with disease (AWD) status in survivors at the end of follow-up, minor gland ACC had more AWD status than major gland ACC significantly. Conclusions ACCs in minor salivary gland had more rapid regional recurrence, frequent distant metastasis and higher alive with disease status than ACCs in major salivary gland.