Abstract
Suboptimal medication adherence among individuals with chronic conditions is a significant clinical problem. However, the evidence on actual self-reported medication-related morbidity due to nonadherence to long-term medications in clinical practice is limited. Such evidence is needed to facilitate implementing interventions to improve the management and outcomes of long-term medication therapies. The objectives of this study was to analyze whether self-reported adverse drug reactions (ADRs) and subtherapeutic effects (STEs) were more common for medications with nonadherent use compared with those with adherent use.
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