PP.42.01

Abstract

Objective: Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in the regulation of renal Na+ reabsorption and K+ secretion as well as blood pressure (BP). The aim of this study was to investigate whether common variants in SGK1 gene are involved in BP responses to dietary sodium intervention or potassium supplementation. Design and method: 344 subjects from 126 families were recruited from rural areas of Northern China. After a 3-day baseline observation, they were sequentially maintained on a 7-day low-sodium diet (3 g of NaCl or 51.3mmol of sodium per day), a 7-day high-sodium diet (18 g of NaCl or 307.8mmol of sodium per day) and a 7-day high-sodium plus potassium supplementation intervention (4.5 g of KCl or 60mmol/d potassium per day). Six single nucleotide polymorphisms (SNPs) were selected from the SGK1 gene. Results: SGK1 SNP rs3813344 was significantly associated with baseline systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) (P = 0.049, 0.015 and 0.018, respectively), and rs9389154 was associated with SBP at baseline (P = 0.040) after adjustment for multiple testing. In addition, rs9376026 was associated with DBP and MAP responses to low-sodium intervention significantly (P = 0.018 and 0.022, respectively). However, no associations between 6 SNPs in the SGK1 gene and BP responses to high-sodium or high-sodium plus potassium-supplementation intervention reached statistical significance. Conclusions: Our study indicates that SGK1 genetic variants may have an important role in BP response to dietary sodium intervention or potassium supplementation and BP regulation.